Authors
Christine Daniels, Paul Krack, Jens Volkmann, Jan Raethjen, Markus O Pinsker, Manja Kloss, Volker Tronnier, Alfons Schnitzler, Lars Wojtecki, Kai Bötzel, Adrian Danek, Rüdiger Hilker, Volker Sturm, Andreas Kupsch, Elfriede Karner, Günther Deuschl, Karsten Witt
Publication date
2011/12
Journal
Movement disorders
Volume
26
Issue
14
Pages
2516-2521
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Description
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in PD. However, QoL fails to improve in a relevant proportion of patients. We studied clinical baseline and progression parameters associated with improvement in QoL after DBS. Data from a German randomized, controlled study comparing DBS (60 patients) with best medical treatment (59 patients) were analyzed. Changes in patients' QoL were assessed using the Parkinson's Disease Questionnaire (PDQ‐39) at baseline and at the 6‐month follow‐up. For the STN‐DBS patients, the changes in PDQ‐39 were correlated with predefined clinical preoperative and progression parameters. Scores for QoL improved after STN‐DBS for 57% of the patients, and for 43% patients, they did not improve. Patients with improvement in QoL showed significantly higher cumulative daily “off” time. Changes in the PDQ‐39 …
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Scholar articles
C Daniels, P Krack, J Volkmann, J Raethjen… - Movement disorders, 2011