Authors
David S Corcoran, Robin Young, David Adlam, Alex McConnachie, Kenneth Mangion, David Ripley, David Cairns, Julia Brown, Chiara Bucciarelli-Ducci, Rajesh Kharbanda, Keith G Oldroyd, Gerry P McCann, John P Greenwood, Colin Berry
Publication date
2018/1/1
Source
Heart
Volume
104
Issue
Suppl 1
Pages
A1-A1
Publisher
BMJ Publishing Group Ltd and British Cardiovascular Society
Description
Background
In patients with angina undergoing invasive diagnostic management, no obstructive coronary artery disease (CAD) is a common finding. Coronary microvascular dysfunction may be relevant. We aimed to assess the prevalence of abnormal coronary microvascular function in patients with suspected CAD.
Methods
CE-MARC 2 was a prospective multicentre randomised trial of functional imaging vs guideline-based management in patients with suspected CAD. Invasive angiography was protocol-directed based on the presence of inducible ischaemia on non-invasive stress testing, or directly as per NICE guideline care. Fractional flow reserve (FFR) and microvascular function (coronary flow reserve (CFR), index of microcirculatory resistance (IMR), resistance reserve ratio (RRR)) were measured in major epicardial vessels with stenosis ≥40-≤90%.
Results
267/1202 (22.2%) patients underwent …
Scholar articles
DS Corcoran, R Young, D Adlam, A McConnachie… - 2018