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To examine acute changes in muscle thickness (MT), isometric strength (ISO), and blood pressure (BP), following exercise with 40% limb occlusion pressure (LOP) using two distinct blood flow restriction (BFR) devices. Forty-four trained individuals had each arm randomized to perform exercise with either a SmartCuffs or Hokanson BFR device. Each condition performed 4 sets to volitional muscular failure at 30% of individual’s one repetition-maximum (1RM) with 30s rest periods. For both conditions, LOP was set at 40%. Blood pressure, MT, and ISO were measured before and after exercise. For MT, there was no condition x time interaction (p= 0.68), or main effect for condition (p= 0.50), however, there was a main effect for time (p< 0.001). When examining changes, MT increased from pre (3.8+/-. 67 cm) to post (4.3+/-. 72 cm). For ISO, there was no condition x time interaction (p= 0.53), or main effect for condition (p= 0.50). However, there was a main effect for time (p< 0.001). When examining changes, ISO decreased from pre (23.7+/-8.5 AU) to post (13.2+/-5.6 AU). For systolic BP, there was no condition x time interaction (p= 0.1), or main effect for condition (p= 0.52). However, there was a main effect for time (p< 0.001). Systolic BP increased from pre (122+/-12 mmHg) to post (136+/-19 mmHg). For diastolic BP, there was no condition x time interaction (p= 0.56), or main effect for condition (p= 0.44). However, there was a main effect for time (p< 0.001). Diastolic BP increased from pre (72+/-9 mmHg) to post (78+/-13 mmHg). In conclusion, we observed significant increases in MT and BP, as well as …