Authors
Fangyuan Yan, Hanmin Liu, Hanyue Zhang, Ling Yi, Yangyang Wu, Changfei Deng, Yang Qiu, Xia Ma, Qi Li, Fumo Yang, Wenli Xu, Jing Tao, Jonathan J Buonocore, Yu Zhan, Li Dai
Publication date
2021/9/1
Journal
Environmental Research
Volume
200
Pages
111472
Publisher
Academic Press
Description
Background
The association between maternal exposure to gaseous air pollutants and congenital heart defects (CHD) remains unclear. The concentration-response relationship and the time windows of susceptibility to gaseous pollutants may vary by pollutant species and CHD subtypes.
Objective
We aimed to examine the relationship between maternal exposures to four species of gaseous pollutants (NO2, O3, SO2, and CO) and atrial septal defect (ASD), which is a common subtype of CHD, and to determine the critical time windows of susceptibility for each gaseous pollutant.
Methods
Among 1,253,633 infants born between October 1, 2013 and December 31, 2016 in China, 1937 newborns were diagnosed with isolated ASD, a prevalence of 1.55‰. Maternal exposures to the gaseous pollutants were estimated by matching the geocoded maternal addresses with the gridded ambient concentrations. The adjusted …
Total citations
Scholar articles
F Yan, H Liu, H Zhang, L Yi, Y Wu, C Deng, Y Qiu, X Ma… - Environmental Research, 2021