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Andean glaciers are among the fastest shrinking and largest contributors to sea level rise on Earth. They also represent crucial water resources in many tropical and semi-arid mountain catchments. Yet the magnitude of the recent ice loss is still debated. Here we present Andean glacier mass changes (from 10° N to 56° S) between 2000 and 2018 using time series of digital elevation models derived from ASTER stereo images. The total mass change over this period was −22.9 ± 5.9 Gt yr⁻¹ (−0.72 ± 0.22 m w.e. yr⁻¹ (m w.e., metres of water equivalent)), with the most negative mass balances in the Patagonian Andes (−0.78 ± 0.25 m w.e. yr⁻¹) and the Tropical Andes (−0.42 ± 0.24 m w.e. yr⁻¹), compared to relatively moderate losses (−0.28 ± 0.18 m w.e. yr⁻¹) in the Dry Andes. Subperiod analysis (2000–2009 versus 2009–2018) revealed a steady mass loss in the tropics and south of 45° …