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We investigate the relationship of morality and political orientation by focusing on the influential results showing that liberals and conservatives rely on different moral foundations. We conducted a comprehensive literature search from major databases and other sources for primary studies that used the Moral Foundations Questionnaire and a typical measure of political orientation, a political self-placement item. We used a predefined process for independent extraction of effect sizes by two authors and ran both study-level and individual-level analyses. With 89 samples, 605 effect sizes, and 33,804 independent participants, in addition to 192,870 participants from the widely used YourMorals. org website, the basic differences about conservatives and liberals are supported. Yet, heterogeneity is moderate, and the results may be less generalizable across samples and political cultures than previously thought. The …