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In NeuroEvolution, the topologies of artificial neural networks are optimized with evolutionary algorithms to solve tasks in data regression, data classification, or reinforcement learning. One downside of NeuroEvolution is the large amount of necessary fitness evaluations, which might render it inefficient for tasks with expensive evaluations, such as real-time learning. For these expensive optimization tasks, surrogate model-based optimization is frequently applied as it features a good evaluation efficiency. While a combination of both procedures appears as a valuable solution, the definition of adequate distance measures for the surrogate modeling process is difficult. In this study, we will extend cartesian genetic programming of artificial neural networks by the use of surrogate model-based optimization. We propose different distance measures and test our algorithm on a replicable benchmark task. The …