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In this paper we study elliptic partial differential equations with rapidly varying diffusion coefficient that can be represented as a perturbation of a reference coefficient. We develop a numerical method for efficiently solving multiple perturbed problems by reusing local computations performed with the reference coefficient. The proposed method is based on the Petrov--Galerkin localized orthogonal decomposition (PG-LOD), which allows for straightforward parallelization with low communication overhead and memory consumption. We focus on two types of perturbations: local defects, which we treat by recomputation of multiscale shape functions, and global mappings of a reference coefficient for which we apply the domain mapping method. We analyze the proposed method for these problem classes and present several numerical examples.