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We investigate numerically the heat transfer and fluid flow characteristics inside a wavy walled enclosure. Second law of thermodynamics is also applied to predict the nature of irreversibility in terms of entropy generation. Finite-volume method is used to discretize the governing differential equations with non-staggered variable arrangement. SIP (strongly implicit procedure) solver solves the linear equation systems with full multigrid (FMG) acceleration. Simulation was carried out for a range of wave ratio (defined by amplitude/average width) λ=0.0–0.4, aspect ratio (defined by height/average width) A=1.0–2.0, Rayleigh number Ra=10⁰–10⁷ for a fluid having Prandtl number equal to 0.7. The angle of inclination (θ) is varied from 0° to 360° with 15° interval. Streamlines and isothermal lines represent the corresponding flow and thermal fields. Local and global Nusselt number distributions express the rate of heat …