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This article addresses a challenging industrial problem known as the unrelated parallel machine scheduling problem (UPMSP) with sequence-dependent setup times. In UPMSP, we have a set of machines and a group of jobs. The goal is to find the optimal way to schedule jobs for execution by one of the several available machines. UPMSP has been classified as an NP-hard optimisation problem and, thus, cannot be solved by exact methods. Meta-heuristic algorithms are commonly used to find sub-optimal solutions. However, large-scale UPMSP instances pose a significant challenge to meta-heuristic algorithms. To effectively solve a large-scale UPMSP, this article introduces a two-stage evolutionary variable neighbourhood search (EVNS) methodology. The proposed EVNS integrates a variable neighbourhood search algorithm and an evolutionary descent framework in an adaptive manner. The proposed …