Authors
Trond Velde Bogsrud, Ian D Hay, Dimitrios Karantanis, Mark A Nathan, Brian P Mullan, Gregory A Wiseman, Jan L Kasperbauer, Carl C Reading, Trine Björo, Val J Lowe
Publication date
2011/4/1
Journal
Nuclear medicine communications
Volume
32
Issue
4
Pages
245-251
Publisher
LWW
Description
Objective
To explore the prognostic value of 18 F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) in radioiodine-negative patients with differentiated follicular cell-derived thyroid carcinoma with circulating antithyroglobulin autoantibodies (TgAb).
Methods
We retrospectively reviewed cases of all patients with differentiated thyroid cancer and increased TgAb referred for FDG-PET at Mayo Clinic, Rochester, Minnesota, from August 2001 to December 2004. PET findings were compared with results of other imaging and laboratory studies. Follow-up information was recorded until 19 December 2009.
Results
Of the 17 patients identified, PET results were true positive in 10 and false negative in two. In eight of these 12 patients with confirmed residual or recurrent disease, the increased TgAb level persisted and the disease progressed. In four of the 12 patients, TgAb decreased or disappeared after further …
Scholar articles
TV Bogsrud, ID Hay, D Karantanis, MA Nathan… - Nuclear medicine communications, 2011