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This study examines the perceived relationships between satisfaction in the areas of life patients consider most important and the constraints imposed on them by the disease and treatment (45 patients with leukemia aged 7–16 years; tools: SEIQoL-DW and the PedsQL cancer module). For children aged 7–11, health-related quality of life is associated with satisfaction in relation to family and physical activity. For adolescents, the relationships are more complex. In conclusion, the study highlights the need to vary management strategies according to age.