Authors
Mark B Gerstein, Zhi John Lu, Eric L Van Nostrand, Chao Cheng, Bradley I Arshinoff, Tao Liu, Kevin Y Yip, Rebecca Robilotto, Andreas Rechtsteiner, Kohta Ikegami, Pedro Alves, Aurelien Chateigner, Marc Perry, Mitzi Morris, Raymond K Auerbach, Xin Feng, Jing Leng, Anne Vielle, Wei Niu, Kahn Rhrissorrakrai, Ashish Agarwal, Roger P Alexander, Galt Barber, Cathleen M Brdlik, Jennifer Brennan, Jeremy Jean Brouillet, Adrian Carr, Ming-Sin Cheung, Hiram Clawson, Sergio Contrino, Luke O Dannenberg, Abby F Dernburg, Arshad Desai, Lindsay Dick, Andréa C Dosé, Jiang Du, Thea Egelhofer, Sevinc Ercan, Ghia Euskirchen, Brent Ewing, Elise A Feingold, Reto Gassmann, Peter J Good, Phil Green, Francois Gullier, Michelle Gutwein, Mark S Guyer, Lukas Habegger, Ting Han, Jorja G Henikoff, Stefan R Henz, Angie Hinrichs, Heather Holster, Tony Hyman, A Leo Iniguez, Judith Janette, Morten Jensen, Masaomi Kato, W James Kent, Ellen Kephart, Vishal Khivansara, Ekta Khurana, John K Kim, Paulina Kolasinska-Zwierz, Eric C Lai, Isabel Latorre, Amber Leahey, Suzanna Lewis, Paul Lloyd, Lucas Lochovsky, Rebecca F Lowdon, Yaniv Lubling, Rachel Lyne, Michael MacCoss, Sebastian D Mackowiak, Marco Mangone, Sheldon McKay, Desirea Mecenas, Gennifer Merrihew, David M Miller III, Andrew Muroyama, John I Murray, Siew-Loon Ooi, Hoang Pham, Taryn Phippen, Elicia A Preston, Nikolaus Rajewsky, Gunnar Rätsch, Heidi Rosenbaum, Joel Rozowsky, Kim Rutherford, Peter Ruzanov, Mihail Sarov, Rajkumar Sasidharan, Andrea Sboner, Paul Scheid, Eran Segal, Hyunjin Shin, Chong Shou, Frank J Slack, Cindie Slightam, Richard Smith, William C Spencer, EO Stinson, Scott Taing, Teruaki Takasaki, Dionne Vafeados, Ksenia Voronina, Guilin Wang, Nicole L Washington, Christina M Whittle, Beijing Wu, Koon-Kiu Yan, Georg Zeller, Zheng Zha, Mei Zhong, Xingliang Zhou, modENCODE Consortium, Julie Ahringer, Susan Strome, Kristin C Gunsalus, Gos Micklem, X Shirley Liu, Valerie Reinke, Stuart K Kim, LaDeana W Hillier, Steven Henikoff, Fabio Piano, Michael Snyder, Lincoln Stein, Jason D Lieb, Robert H Waterston
Publication date
2010/12/24
Journal
Science
Volume
330
Issue
6012
Pages
1775-1787
Publisher
American Association for the Advancement of Science
Description
We systematically generated large-scale data sets to improve genome annotation for the nematode Caenorhabditis elegans, a key model organism. These data sets include transcriptome profiling across a developmental time course, genome-wide identification of transcription factor–binding sites, and maps of chromatin organization. From this, we created more complete and accurate gene models, including alternative splice forms and candidate noncoding RNAs. We constructed hierarchical networks of transcription factor–binding and microRNA interactions and discovered chromosomal locations bound by an unusually large number of transcription factors. Different patterns of chromatin composition and histone modification were revealed between chromosome arms and centers, with similarly prominent differences between autosomes and the X chromosome. Integrating data types, we built statistical models …
Total citations
Scholar articles
MB Gerstein, ZJ Lu, EL Van Nostrand, C Cheng… - Science, 2010