Authors
Steve E Calvano, Wenzhong Xiao, Daniel R Richards, Ramon M Felciano, Henry V Baker, Raymond J Cho, Richard O Chen, Bernard H Brownstein, J Perren Cobb, S Kevin Tschoeke, Carol Miller-Graziano, Lyle L Moldawer, Michael N Mindrinos, Ronald W Davis, Ronald G Tompkins, Stephen F Lowry, Inflammation and Host Response to Injury Large Scale Collaborative Research Program
Publication date
2005/10/13
Journal
Nature
Volume
437
Issue
7061
Pages
1032-1037
Publisher
Nature Publishing Group UK
Description
Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically similar tumours, monitor disease progress, and individualize treatment regimens,,,,. However, extracting new biological insight from high-throughput genomic studies of human diseases is a challenge, limited by difficulties in recognizing and evaluating relevant biological processes from huge quantities of experimental data. Here we present a structured network knowledge-base approach to analyse genome-wide transcriptional responses in the context of known functional interrelationships among proteins, small molecules and phenotypes. This approach was used to analyse changes in blood leukocyte gene expression patterns in human subjects receiving an inflammatory stimulus (bacterial endotoxin). We explore the known genome-wide interaction network to identify significant functional modules perturbed in …
Total citations
Scholar articles
SE Calvano, W Xiao, DR Richards, RM Felciano… - Nature, 2005