Authors
David Kerk, Joshua Bulgrien, Douglas W Smith, Brooke Barsam, Stella Veretnik, Michael Gribskov
Publication date
2002/6/1
Journal
Plant physiology
Volume
129
Issue
2
Pages
908-925
Publisher
American Society of Plant Biologists
Description
Reversible protein phosphorylation is critically important in the modulation of a wide variety of cellular functions. Several families of protein phosphatases remove phosphate groups placed on key cellular proteins by protein kinases. The complete genomic sequence of the model plant Arabidopsis permits a comprehensive survey of the phosphatases encoded by this organism. Several errors in the sequencing project gene models were found via analysis of predicted phosphatase coding sequences. Structural sequence probes from aligned and unaligned sequence models, and all-against-all BLAST searches, were used to identify 112 phosphatase catalytic subunit sequences, distributed among the serine (Ser)/threonine (Thr) phosphatases (STs) of the protein phosphatase P (PPP) family, STs of the protein phosphatase M (PPM) family (protein phosphatases 2C [PP2Cs] subfamily), protein tyrosine (Tyr …
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D Kerk, J Bulgrien, DW Smith, B Barsam, S Veretnik… - Plant physiology, 2002