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Impulse radio-ultra wideband (IR-UWB) communication technique is considered as a strong candidate for short range biomedical wireless sensor networks (BWSN). Coexistence with other systems in the ISM band is important, where narrow band interference (NBI) can become a threat to this system. This paper proposes a method to increase robustness of IR-UWB system in the existence of NBI. This method takes the advantage of using both FEC coding and frequency interleaving technique. One of the features of the proposed system is that it performs well in an environment with unknown NBI. Comparisons between single-band and multi-band signaling schemes are given. Simulation results show that the proposed multi-band scheme performs well in existence of NBI and provides about 3.5 dB gain in comparison to single-band scheme with the same configuration, where the NBI to AWGN energy ratio equals 30 …