Authors
Michael L Alosco, Adam M Brickman, Mary Beth Spitznagel, Sarah L Garcia, Atul Narkhede, Erica Y Griffith, Naftali Raz, Ronald Cohen, Lawrence H Sweet, Lisa H Colbert, Richard Josephson, Joel Hughes, Jim Rosneck, John Gunstad
Publication date
2013/7
Journal
Congestive heart failure
Volume
19
Issue
4
Pages
E29-E34
Description
Cognitive impairment is common in heart failure (HF) and believed to be the result of cerebral hypoperfusion and subsequent brain changes including white matter hyperintensities (WMHs). The current study examined the association between cerebral blood flow and WMHs in patients with HF and the relationship between WMHs and cognitive impairment. Sixty‐nine patients with HF completed the Mini‐Mental State Examination (MMSE) and underwent echocardiography, transcranial Doppler sonography for cerebral blood flow velocity of the middle cerebral artery, and brain magnetic resonance imaging. Multivariable hierarchical regression analyses controlling for medical and demographic characteristics as well as intracranial volume showed reduced cerebral blood flow velocity of the middle cerebral artery was associated with greater WMHs (β=−0.34, P=.02). Follow‐up regression analyses adjusting for the …
Scholar articles
ML Alosco, AM Brickman, MB Spitznagel, SL Garcia… - Congestive heart failure, 2013