Authors
Mohammad R Seyedsayamdost, Josephine R Chandler, Joshua AV Blodgett, Patricia S Lima, Breck A Duerkop, Ken-Ichi Oinuma, E Peter Greenberg, Jon Clardy
Publication date
2010/2/19
Journal
Organic letters
Volume
12
Issue
4
Pages
716-719
Publisher
American Chemical Society
Description
Bacterial acyl-homoserine lactones upregulated an uncharacterized gene cluster (bta) in Burkholderia thailandensis E264 to produce an uncharacterized polar antibiotic. The antibiotic is identified as a mixture of four bactobolins. Annotation of the bta cluster allows us to propose a biosynthetic scheme for bactobolin and reveals unusual enzymatic reactions for further study.
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Scholar articles
MR Seyedsayamdost, JR Chandler, JAV Blodgett… - Organic letters, 2010