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Although a significant amount of research on the blast response of structural components has been conducted, scarce information is available on the effects of cylindrical charge orientation. Available literature mentioned that the orientation of a cylindrical charge with respect to the target structures can substantially influence blast wave parameters when compared to a spherical charge of same mass. Most standards and guidelines related to blast-resistant design are silent on this issue. Thus, an experimental study was conducted to investigate the effects of cylindrical charge orientation on the blast response of typical high strength concrete (HSC) flexural panels. Moreover, to obtain the reflected blast wave parameters, a steel plate with pressure sensors mounted on it was tested under the same blast loading conditions. The experimental results showed significant difference in the blast response of the panels (i.e …