Authors
Alexander LN van Nuijs, Isabela Tarcomnicu, Lieven Bervoets, Ronny Blust, Philippe G Jorens, Hugo Neels, Adrian Covaci
Publication date
2009/10
Journal
Analytical and bioanalytical chemistry
Volume
395
Pages
819-828
Publisher
Springer-Verlag
Description
The simultaneous analysis of nine drugs of abuse (DOAs) and their metabolites (amphetamine, methamphetamine, methylenedioxymethamphetamine, methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, cocaine, benzoylecgonine, ecgonine methyl ester and 6-monoacetylmorphine) in wastewater based on hydrophilic interaction liquid chromatography (HILIC) coupled to tandem mass spectrometry (MS/MS) was optimised and validated. For each analyte, the deuterated analogue was used for quantification. The separation by HILIC showed good performance for all compounds, especially for the hydrophilic compounds, which elute early (amphetamine-like stimulants) or show no retention (ecgonine methyl ester) in reversed-phase liquid chromatography. Sample preparation based on solid-phase extraction was optimised by comparing Oasis HLB and Oasis MCX sorbents for various parameters …
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Scholar articles
ALN van Nuijs, I Tarcomnicu, L Bervoets, R Blust… - Analytical and bioanalytical chemistry, 2009