Authors
Jeffrey L Carson, Simon J Stanworth, Gordon Guyatt, Stacey Valentine, Jane Dennis, Sara Bakhtary, Claudia S Cohn, Allan Dubon, Brenda J Grossman, Gaurav K Gupta, Aaron S Hess, Jessica L Jacobson, Lewis J Kaplan, Yulia Lin, Ryan A Metcalf, Colin H Murphy, Katerina Pavenski, Micah T Prochaska, Jay S Raval, Eric Salazar, Nabiha H Saifee, Aaron AR Tobian, Cynthia So-Osman, Jonathan Waters, Erica M Wood, Nicole D Zantek, Monica B Pagano
Publication date
2023/11/21
Journal
Jama
Volume
330
Issue
19
Pages
1892-1902
Publisher
American Medical Association
Description
Importance
Red blood cell transfusion is a common medical intervention with benefits and harms.
Objective
To provide recommendations for use of red blood cell transfusion in adults and children.
Evidence Review
Standards for trustworthy guidelines were followed, including using Grading of Recommendations Assessment, Development and Evaluation methods, managing conflicts of interest, and making values and preferences explicit. Evidence from systematic reviews of randomized controlled trials was reviewed.
Findings
For adults, 45 randomized controlled trials with 20 599 participants compared restrictive hemoglobin-based transfusion thresholds, typically 7 to 8 g/dL, with liberal transfusion thresholds of 9 to 10 g/dL. For pediatric patients, 7 randomized controlled trials with 2730 participants compared a variety of restrictive and liberal transfusion thresholds. For most patient populations, results provided …
Total citations
Scholar articles
JL Carson, SJ Stanworth, G Guyatt, S Valentine… - Jama, 2023