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A combined system including sonocatalysis and photocatalysis was applied for catalytic degradation of tetracycline (TC) antibiotic using TiO₂ decorated on magnetic activated carbon (MAC@T) in coupling with ultraviolet (UV) and ultrasound (US) irradiations. MAC was fabricated via magnetization of AC using Fe₃O₄ nanoparticles. FESEM, EDS, TEM, BET, XRD, PL, VSM and UV–visible DRS techniques were used to characterize the catalyst features. The performance of MAC@T/UV/US system was examined under impact of different input variable such as catalyst loading, solution pH, initial TC concentration, US power, scavenging agents, chemical oxidants and co-exiting anions. The degradation rate was enhanced substantially when MAC@T coupled with US and UV irradiations. At optimal conditions, over 93% TC and 50% TOC were removed under 180 min reaction. Whereas, the complete removal of TC was …