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Background/Introduction: Since the phenotypic expression of Hypertrophic Cardiomyopathy (HCM) is variable and some patients express only mild left ventricular hypertrophy (LVH), the differentiation between genotype-positive HCM and genotype-negative causes of LVH can be challenging. Myocardial deformation imaging can detect early contractile dysfunction, and may therefore be usable in HCM.

Purpose: This cross-sectional study assesses the ability of feature tracking cardiovascular magnetic resonance imaging (FT-CMR) to distinguish between genotype-positive and genotype-negative LVH.

Methods: Monocenter study of 145 patients (27, 6% females, 51, 13±14.29 years) who had a maximum myocardial wall thickness (MMWT)≥ 13mm on good quality CMR and underwent genetic testing in the University Medical Center Utrecht. We excluded patients if no clinical information was available or if there was a …