Authors
Irina Filippi, André Galinowski, Hervé Lemaître, Christian Massot, Pascal Zille, Pauline Frère, Rubén Miranda-Marcos, Christian Trichard, Stella Guldner, Hélène Vulser, Marie-Laure Paillère-Martinot, Erin Burke Quinlan, Sylvane Desrivieres, Penny Gowland, Arun Bokde, Hugh Garavan, Andreas Heinz, Henrik Walter, Laura Daedelow, Christian Büchel, Uli Bromberg, Patricia J Conrod, Herta Flor, Tobias Banaschewski, Frauke Nees, Stefan Heintz, Michael Smolka, Nora C Vetter, Dimitri Papadopoulos-Orfanos, Robert Whelan, Louise Poustka, Tomas Paus, Gunter Schumann, Eric Artiges, Jean-Luc Martinot, IMAGEN Consortium
Publication date
2021/8/1
Journal
European Neuropsychopharmacology
Volume
49
Pages
11-22
Publisher
Elsevier
Description
Early initiation of polysubstance use (PSU) is a strong predictor of subsequent addiction, however scarce individuals present resilience capacity. This neuroimaging study aimed to investigate structural correlates associated with cessation or reduction of PSU and determine the extent to which brain structural features accounted for this resilient outcome. Participants from a European community-based cohort self-reported their alcohol, tobacco and cannabis use frequency at ages 14, 16 and 19 and had neuroimaging sessions at ages 14 and 19. We included three groups in the study: the resilient-to-PSU participants showed PSU at 16 and/or 14 but no more at 19 (n = 18), the enduring polysubstance users at 19 displayed PSU continuation from 14 or 16 (n = 193) and the controls were abstinent or low drinking participants (n = 460). We conducted between-group comparisons of grey matter volumes on whole brain …
Total citations
Scholar articles
I Filippi, A Galinowski, H Lemaître, C Massot, P Zille… - European Neuropsychopharmacology, 2021