Authors
Lihui Zhao, Brian Claggett, Lu Tian, Hajime Uno, Marc A Pfeffer, Scott D Solomon, Lorenzo Trippa, LJ Wei
Publication date
2016/3/1
Journal
Biometrics
Volume
72
Issue
1
Pages
215-221
Description
For a study with an event time as the endpoint, its survival function contains all the information regarding the temporal, stochastic profile of this outcome variable. The survival probability at a specific time point, say t, however, does not transparently capture the temporal profile of this endpoint up to t. An alternative is to use the restricted mean survival time (RMST) at time t to summarize the profile. The RMST is the mean survival time of all subjects in the study population followed up to t, and is simply the area under the survival curve up to t. The advantages of using such a quantification over the survival rate have been discussed in the setting of a fixed‐time analysis. In this article, we generalize this approach by considering a curve based on the RMST over time as an alternative summary to the survival function. Inference, for instance, based on simultaneous confidence bands for a single RMST curve and also the …
Total citations
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Scholar articles
L Zhao, B Claggett, L Tian, H Uno, MA Pfeffer… - Biometrics, 2016