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Real-time event detection and targeted decision making for emerging mission-critical applications require systems that extract and process relevant data from IoT sources in smart spaces. Oftentimes, this data is heterogeneous in size, relevance, and urgency, which creates a challenge when considering that different groups of stakeholders (e.g., first responders, medical staff, government officials, etc.) require such data to be delivered in a reliable and timely manner. Furthermore, in mission-critical settings, networks can become constrained due to lossy channels and failed components, which ultimately add to the complexity of the problem. In this article, we propose PrioDeX, a cross-layer middleware system that enables timely and reliable delivery of mission-critical data from IoT sources to relevant consumers through the prioritization of messages. It integrates parameters at the application, network, and …