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Real-time event detection and targeted decision making for emerging mission-critical applications, e.g. smart fire fighting, requires systems that extract and process relevant data from connected IoT devices in the environment. In this paper, we propose FireDeX, a cross-layer middleware that facilitates timely and effective exchange of data for coordinating emergency response activities. FireDeX adopts a publish-subscribe data exchange paradigm with brokers at the network edge to manage prioritized delivery of mission-critical data from IoT sources to relevant subscribers. It incorporates parameters at the application, network, and middleware layers into a data exchange service that accurately estimates end-to-end performance metrics (e.g. delays, success rates). We design an extensible queueing theoretic model that abstracts these cross-layer interactions as a network of queues, thereby making it amenable for …