Authors
Louise EJ Thomson, Janet Wei, Megha Agarwal, Afsaneh Haft-Baradaran, Chrisandra Shufelt, Puja K Mehta, Edward B. Gill, B Delia Johnson, Tanya Kenkre, Eileen M. Handberg, Debiao Li, Behzad Sharif, Daniel S Berman, John W. Petersen, Carl J Pepine, C Noel Bairey Merz
Publication date
2015/4
Journal
Circulation: Cardiovascular Imaging
Volume
8
Issue
4
Pages
e002481
Publisher
Lippincott Williams & Wilkins
Description
Background
Women with signs and symptoms of ischemia and no obstructive coronary artery disease often have coronary microvascular dysfunction (CMD), diagnosed by invasive coronary reactivity testing (CRT). Although traditional noninvasive stress imaging is often normal in CMD, cardiac MRI may be able to detect CMD in this population.
Methods and Results
Vasodilator stress cardiac MRI was performed in 118 women with suspected CMD who had undergone CRT and 21 asymptomatic reference subjects. Semi-quantitative evaluation of the first-pass perfusion images was completed to determine myocardial perfusion reserve index (MPRI). The relationship between CRT findings and MPRI was examined by Pearson correlations, logistic regression, and sensitivity/specificity. Symptomatic women had lower mean pharmacological stress MPRI compared with reference subjects (1.71±0.43 versus 2.23±0.37; P …
Scholar articles
LEJ Thomson, J Wei, M Agarwal, A Haft-Baradaran… - Circulation: Cardiovascular Imaging, 2015