Authors
Wilma S Leslie, Ian Ford, Naveed Sattar, Kieren G Hollingsworth, Ashley Adamson, Falko F Sniehotta, Louise McCombie, Naomi Brosnahan, Hazel Ross, John C Mathers, Carl Peters, George Thom, Alison Barnes, Sharon Kean, Yvonne McIlvenna, Angela Rodrigues, Lucia Rehackova, Sviatlana Zhyzhneuskaya, Roy Taylor, Mike EJ Lean
Publication date
2016/12
Journal
BMC family practice
Volume
17
Pages
1-10
Publisher
BioMed Central
Description
Background
Despite improving evidence-based practice following clinical guidelines to optimise drug therapy, Type 2 diabetes (T2DM) still exerts a devastating toll from vascular complications and premature death. Biochemical remission of T2DM has been demonstrated with weight loss around 15kg following bariatric surgery and in several small studies of non-surgical energy-restriction treatments. The non-surgical Counterweight-Plus programme, running in Primary Care where obesity and T2DM are routinely managed, produces >15 kg weight loss in 33 % of all enrolled patients. The Diabetes UK-funded Counterpoint study suggested that this should be sufficient to reverse T2DM by removing ectopic fat in liver and pancreas, restoring first-phase insulin secretion.
The Diabetes Remission Clinical Trial (DiRECT) was designed to determine whether a structured, intensive …
Scholar articles
WS Leslie, I Ford, N Sattar, KG Hollingsworth… - BMC family practice, 2016