Authors
G Thom, C‐M Messow, WS Leslie, AC Barnes, N Brosnahan, L McCombie, A Al‐Mrabeh, S Zhyzhneuskaya, P Welsh, N Sattar, R Taylor, MEJ Lean
Publication date
2021/8
Journal
Diabetic Medicine
Volume
38
Issue
8
Pages
e14395
Description
Aim
To identify predictors of type 2 diabetes remission in the intervention arm of DiRECT (Diabetes Remission Clinical Trial).
Methods
Participants were aged 20–65 years, with type 2 diabetes duration of <6 years and BMI 27–45 kg/m2, and were not receiving insulin. Weight loss was initiated by total diet replacement (825–853 kcal/day, 3–5 months, shakes/soups), and weight loss maintenance support was provided for 2 years. Remissions (HbA1c <48 mmol/mol [<6.5%], without antidiabetes medications) in the intervention group (n = 149, mean age 53 years, BMI 35 kg/m2) were achieved by 68/149 participants (46%) at 12 months and by 53/149 participants (36%) at 24 months. Potential predictors were examined by logistic regression analyses, with adjustments for weight loss and effects independent of weight loss.
Results
Baseline predictors of remission at 12 and 24 months included being prescribed fewer …
Scholar articles
G Thom, CM Messow, WS Leslie, AC Barnes… - Diabetic Medicine, 2021