Authors
George Thom, Alasdair McIntosh, Claudia‐Martina Messow, Wilma S Leslie, Alison C Barnes, Naomi Brosnahan, Louise McCombie, Dalia Malkova, Ahmad Al‐Mrabeh, Sviatlana Zhyzhneuskaya, Paul Welsh, Naveed Sattar, Roy Taylor, Michael EJ Lean
Publication date
2021/3
Journal
Diabetes, Obesity and Metabolism
Volume
23
Issue
3
Pages
711-719
Publisher
Blackwell Publishing Ltd
Description
Aim
To investigate whether appetite‐related hormones were predictors of weight regain in the Diabetes Remission Clinical Trial (DiRECT).
Materials and Methods
DiRECT is a cluster‐randomized clinical trial, designed to assess the effect of weight loss on type 2 diabetes remission. For this post hoc analysis, data were available for 253 (147 interventions, 106 controls) individuals with type 2 diabetes (age 53.6 ± 7.5 years, body mass index 34.7 ± 4.4 kg/m2, 59% men). Intervention participants received a 24‐month weight management programme, and controls remained on usual diabetes care. Fasting plasma concentrations of leptin, ghrelin, glucagon‐like peptide‐1 and peptide YY were measured at baseline, 12 months and 24 months in all participants, and at 5 months in a subset of participants in the intervention (n = 56) and control groups (n = 22). Potential predictors were examined using multivariable …
Total citations
Scholar articles
G Thom, A McIntosh, CM Messow, WS Leslie… - Diabetes, Obesity and Metabolism, 2021