Authors
Anthony A Ryan, Jonathan K Nambiar, Teresa M Wozniak, Ben Roediger, Elena Shklovskaya, Warwick J Britton, Barbara Fazekas de St Groth, James A Triccas
Publication date
2009/6/1
Journal
The Journal of Immunology
Volume
182
Issue
11
Pages
7172-7177
Publisher
American Association of Immunologists
Description
One reason proposed for the failure of Mycobacterium bovis bacille Calmette Guérin (BCG) vaccination to adequately control the spread of tuberculosis is a limited ability of the vaccine to induce effective CD8 T cell responses. However, the relative capacity of the BCG vaccine and virulent Mycobacterium tuberculosis to induce activation of CD8 T cells, and the factors that govern the initial priming of these cells after mycobacterial infection, are poorly characterized. Using a TCR transgenic CD8 T cell transfer model, we demonstrate significant activation of Ag-specific CD8 T cells by BCG, but responses were delayed and of reduced magnitude compared with those following infection with M. tuberculosis. The degree of CD8 T cell activation was critically dependent on the level of antigenic stimulation, as modifying the infectious dose to achieve comparable numbers of BCG or M. tuberculosis in draining lymph nodes …
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AA Ryan, JK Nambiar, TM Wozniak, B Roediger… - The Journal of Immunology, 2009