Authors
Peter J Thul, Lovisa Åkesson, Mikaela Wiking, Diana Mahdessian, Aikaterini Geladaki, Hammou Ait Blal, Tove Alm, Anna Asplund, Lars Björk, Lisa M Breckels, Anna Bäckström, Frida Danielsson, Linn Fagerberg, Jenny Fall, Laurent Gatto, Christian Gnann, Sophia Hober, Martin Hjelmare, Fredric Johansson, Sunjae Lee, Cecilia Lindskog, Jan Mulder, Claire M Mulvey, Peter Nilsson, Per Oksvold, Johan Rockberg, Rutger Schutten, Jochen M Schwenk, Åsa Sivertsson, Evelina Sjöstedt, Marie Skogs, Charlotte Stadler, Devin P Sullivan, Hanna Tegel, Casper Winsnes, Cheng Zhang, Martin Zwahlen, Adil Mardinoglu, Fredrik Pontén, Kalle Von Feilitzen, Kathryn S Lilley, Mathias Uhlén, Emma Lundberg
Publication date
2017/5/26
Journal
Science
Volume
356
Issue
6340
Pages
eaal3321
Publisher
American Association for the Advancement of Science
Description
INTRODUCTION
A complete view of human biology can only be achieved by studying the molecular components of its smallest functional unit, the cell. Cells are internally organized into compartments called organelles. The spatial partitioning provided by organelles creates an enclosed environment or surface for chemical reactions tailored to fulfill specific functions. These functions are tightly linked to a specific set of proteins. Therefore, resolving the subcellular location of the human proteome provides information about the function of the organelle and its underlying cellular mechanisms. We present a subcellular map of the human proteome, called the Cell Atlas, to facilitate functional exploration of individual proteins and their role in human biology and disease.
RATIONALE
Immunofluorescence (IF) microscopy was used to systematically resolve the spatial distribution of human proteins in cultivated cell lines …
Scholar articles
PJ Thul, L Åkesson, M Wiking, D Mahdessian… - Science, 2017