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Problems with multiple interdependent components offer a better representation of the real-world situations where globally optimal solutions are preferred over optimal solutions for the individual components. One such model is the Travelling Thief Problem (TTP); while it may offer a better benchmarking alternative to the standard models, only one form of inter-component dependency is investigated. The goal of this paper is to study the impact of different models of dependency on the fitness landscape using performance prediction models (regression analysis). To conduct the analysis, we consider a generalised model of the TTP, where the dependencies between the two components of the problem are tunable through problem features. We use regression trees to predict the instance difficulty using an efficient memetic algorithm that is agnostic to the domain knowledge to avoid any bias. We report all the decision …