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Spatial data are often derived from multiple sources (e.g. satellites, in-situ sensors, survey samples) with different supports, but associated with the same properties of a spatial phenomenon of interest. It is common for predictors to also be measured on different spatial supports than the response variables. Although there is no standard way to work with spatial data with different supports, a prevalent approach used by practitioners has been to use downscaling or interpolation to project all the variables of analysis towards a common support, and then using standard spatial models. The main disadvantage with this approach is that simple interpolation can introduce biases and, more importantly, the uncertainty associated with the change of support is not taken into account in parameter estimation. In this article, we propose a Bayesian spatial latent Gaussian model that can handle data with different rectilinear supports in both the response variable and predictors. Our approach allows to handle changes of support more naturally according to the properties of the spatial stochastic process being used, and to take into account the uncertainty from the change of support in parameter estimation and prediction. We use spatial stochastic processes as linear combinations of basis functions where Gaussian Markov random fields define the weights. Our hierarchical modelling approach can be described by the following steps: (i) define a latent model where response variables and predictors are considered as latent stochastic processes with continuous support, (ii) link the continuous-index set stochastic processes with its projection to the support of the …