Authors
Maria Pina Dore, Antonietta Pedroni, Gianni M Pes, Emanouil Maragkoudakis, Vincenza Tadeu, Pietro Pirina, Giuseppe Realdi, Giuseppe Delitala, Hoda M Malaty
Publication date
2007/2
Journal
Digestive diseases and sciences
Volume
52
Pages
463-468
Publisher
Kluwer Academic Publishers-Plenum Publishers
Description
The effect of proton pump inhibitor (PPI) therapy on extraesophageal or atypical manifestations of gastroesophageal reflux disease (GERD) remains unclear. This study aimed to evaluate the prevalence of atypical manifestations in patients with acid reflux disease and the effect of PPI treatment. Patients with symptoms and signs suggestive of reflux were enrolled. Erosive esophagitis was stratified using the Los Angeles classification. Demographic data and symptoms were assessed using a questionnaire and included typical symptoms (heartburn, regurgitation, dysphagia, odynophagia), and atypical symptoms (e.g., chest pain, sialorrhea, hoarseness, globus sensation, chronic coughing, episodic bronchospasm, hiccup, eructations, laryngitis, and pharyngitis). Symptoms were reassessed after a 3-month course of b.i.d. PPI therapy. A total of 266 patients with a first diagnosis of GERD (erosive, 166 …
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Scholar articles
MP Dore, A Pedroni, GM Pes, E Maragkoudakis… - Digestive diseases and sciences, 2007