Authors
Mario Maioli, Giovanni Mario Pes, Giuseppe Delitala, L Puddu, Alberto Falorni, Francesco Tolu, Rosanna Lampis, Valeria Orrù, G Secchi, AM Cicalò, R Floris, GF Madau, RM Pilosu, M Whalen, Francesco Cucca
Publication date
2010/10
Journal
European journal of endocrinology
Volume
163
Issue
4
Pages
541-549
Publisher
Oxford University Press
Description
Objective
In latent autoimmune diabetes of adults (LADA), the progression into insulin-dependent diabetes is usually faster than in type 2 diabetes (T2D) but the factors influencing this progression are not completely known. In this study, we searched for sensitive markers associated with early development of insulin dependence.
Design
The screening of 5568 T2D patients for glutamic acid decarboxylase autoantibodies (GAD65Ab) identified 276 LADA patients (M=131; F=145) and in 251 of them, tyrosine phosphatase-2 (IA-2Ab) and thyroperoxidase autoantibodies (TPOAbs), some clinical features and genotype variation of the main type 1 diabetes (T1D) disease susceptibility loci (HLA-DRB1 and HLA-DQB1) were analyzed.
Results
Four years after the diagnosis of diabetes, high GAD65Ab titer was not significantly associated with faster progression …
Total citations
Scholar articles
M Maioli, GM Pes, G Delitala, L Puddu, A Falorni… - European journal of endocrinology, 2010