Authors
Adam M Zysk, Kai Chen, Edward Gabrielson, Lorraine Tafra, Evelyn A May Gonzalez, Joseph K Canner, Eric B Schneider, Andrew J Cittadine, P Scott Carney, Stephen A Boppart, Kimiko Tsuchiya, Kristen Sawyer, Lisa K Jacobs
Publication date
2015/10
Journal
Annals of surgical oncology
Volume
22
Pages
3356-3362
Publisher
Springer US
Description
Background
A multicenter, prospective, blinded study was performed to test the feasibility of using a handheld optical imaging probe for the intraoperative assessment of final surgical margins during breast-conserving surgery (BCS) and to determine the potential impact on patient outcomes.
Methods
Forty-six patients with early-stage breast cancer (one with bilateral disease) undergoing BCS at two study sites, the Johns Hopkins Hospital and Anne Arundel Medical Center, were enrolled in this study. During BCS, cavity-shaved margins were obtained and the final margins were examined ex vivo in the operating room with a probe incorporating optical coherence tomography (OCT) hardware and interferometric synthetic aperture microscopy (ISAM) image processing. Images were interpreted after BCS by three physicians blinded to final pathology …
Scholar articles
AM Zysk, K Chen, E Gabrielson, L Tafra… - Annals of surgical oncology, 2015