Authors
Yann C Klimentidis, David A Raichlen, Jennifer Bea, David O Garcia, Nathan E Wineinger, Lawrence J Mandarino, Gene E Alexander, Zhao Chen, Scott B Going
Publication date
2018/6
Journal
International journal of obesity
Volume
42
Issue
6
Pages
1161-1176
Publisher
Nature Publishing Group UK
Description
Background/objectives
Physical activity (PA) protects against a wide range of diseases. Habitual PA appears to be heritable, motivating the search for specific genetic variants that may inform efforts to promote PA and target the best type of PA for each individual.
Subjects/methods
We used data from the UK Biobank to perform the largest genome-wide association study of PA to date, using three measures based on self-report (nmax = 377,234) and two measures based on wrist-worn accelerometry data (nmax = 91,084). We examined genetic correlations of PA with other traits and diseases, as well as tissue-specific gene expression patterns. With data from the Atherosclerosis Risk in Communities (ARIC; n = 8,556) study, we performed a meta-analysis of our top hits for moderate-to-vigorous PA (MVPA).
Results
We identified ten loci across all PA measures that were significant in both a basic and a fully adjusted …
Scholar articles
YC Klimentidis, DA Raichlen, J Bea, DO Garcia… - International journal of obesity, 2018