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Introduction: Elevated body mass index (BMI) is a risk factor for cardiovascular (CV) events. It remains unclear if the effectiveness and safety of aspirin dose (81mg vs 325mg) is modified by baseline BMI.

Research Question: To determine differences in CV event rates and major bleeding between aspirin dose and BMI in patients with coronary artery disease (CAD).

Methods: Participants from the ADAPTABLE trial were stratified by BMI categories defined as normal weight (BMI <25 kg/m²), overweight (BMI ≥25 to <30 kg/m²), and obese (≥30 kg/m²). The primary outcome was a composite of all cause death, hospitalization for myocardial infarction (MI), or hospitalization for stroke, assessed in a time-to-event analysis. The event rate represented events per 100 patient years of follow up. The primary safety outcome was hospitalization for major bleeding with blood product transfusion. Cox proportional hazards models …