Authors
Bruno Benetti Junta Torres, Fátima Maria Caetano Caldeira, Mardelene Geísa Gomes, Rogéria Serakides, Aline de Marco Viott, Angélica Cavalheiro Bertagnolli, Fabíola Bono Fukushima, Karen Maciel De Oliveira, Marcus Vinícius Gomes, Eliane Gonçalves De Melo
Publication date
2010/12
Journal
International Journal of Experimental Pathology
Volume
91
Issue
6
Pages
530-536
Publisher
Blackwell Publishing Ltd
Description
Dantrolene has been shown to be neuroprotective by reducing neuronal apoptosis after brain injury in several animal models of neurological disorders. In this study, we investigated the effects of dantrolene on experimental spinal cord injury (SCI). Forty‐six male Wistar rats were laminectomized at T13 and divided in six groups: GI (n = 7) underwent SCI with placebo and was euthanized after 32 h; GII (n = 7) underwent laminectomy alone with placebo and was euthanized after 32 h; GIII (n = 8) underwent SCI with dantrolene and was euthanized after 32 h; GIV (n = 8) underwent SCI with placebo and was euthanized after 8 days; GV (n = 8) underwent laminectomy alone with placebo and was euthanized after 8 days; and GVI (n = 8) underwent SCI with dantrolene and was euthanized after 8 days. A compressive trauma was performed to induce SCI. After euthanasia, the spinal cord was …
Scholar articles
BBJ Torres, FMC Caldeira, MG Gomes, R Serakides… - International Journal of Experimental Pathology, 2010