Authors
Juliet E Compston, Julie Flahive, David W Hosmer, Nelson B Watts, Ethel S Siris, Stuart Silverman, Kenneth G Saag, Christian Roux, Maurizio Rossini, Johannes Pfeilschifter, Jeri W Nieves, J Coen Netelenbos, Lyn March, Andrea Z LaCroix, Frederick H Hooven, Susan L Greenspan, Stephen H Gehlbach, Adolfo Díez‐Pérez, Cyrus Cooper, Roland D Chapurlat, Steven Boonen, Frederick A Anderson Jr, Silvano Adami, Jonathan D Adachi, GLOW Investigators
Publication date
2014/2/1
Journal
Journal of bone and mineral research
Volume
29
Issue
2
Pages
487-493
Publisher
John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)
Description
Low body mass index (BMI) is a well‐established risk factor for fracture in postmenopausal women. Height and obesity have also been associated with increased fracture risk at some sites. We investigated the relationships of weight, BMI, and height with incident clinical fracture in a practice‐based cohort of postmenopausal women participating in the Global Longitudinal study of Osteoporosis in Women (GLOW). Data were collected at baseline and at 1, 2, and 3 years. For hip, spine, wrist, pelvis, rib, upper arm/shoulder, clavicle, ankle, lower leg, and upper leg fractures, we modeled the time to incident self‐reported fracture over a 3‐year period using the Cox proportional hazards model and fitted the best linear or nonlinear models containing height, weight, and BMI. Of 52,939 women, 3628 (6.9%) reported an incident clinical fracture during the 3‐year follow‐up period. Linear BMI showed a …
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