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Interest in evaluating non-economic social outcomes of science and technology research has risen in policy circles in recent years. The interest in social impacts of research has not yet given rise to a great proliferation of useful, valid techniques for evaluating such impacts. This study presents detailed case studies of four US National Science Foundation (NSF) programs/initiatives to provide a framework for understanding diverse efforts at addressing social impacts, and to suggest some important gaps in our research approaches for assessing socio-economic impacts of research. The four cases studied − the Experimental Program to Stimulate Competitive Research (EPSCoR), the Innovation Corps (I-Corps), the Arizona State University Center for Nanotechnology in Society, and the NSF “Broader Impacts” criteria—were chosen for their diversity in intent and modality but operating within a single agency. The cases …