Authors
Christine M Ribic, Daniel J Sargent, Malcolm J Moore, Stephen N Thibodeau, Amy J French, Richard M Goldberg, Stanley R Hamilton, Pierre Laurent-Puig, Robert Gryfe, Lois E Shepherd, Dongsheng Tu, Mark Redston, Steven Gallinger
Publication date
2003/7/17
Journal
New England Journal of Medicine
Volume
349
Issue
3
Pages
247-257
Publisher
Massachusetts Medical Society
Description
Background
Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish them from microsatellite-stable tumors. We investigated the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II and stage III colon cancer.
Methods
Tumor specimens were collected from patients with colon cancer who were enrolled in randomized trials of fluorouracil-based adjuvant chemotherapy. Microsatellite instability was assessed with the use of mononucleotide and dinucleotide markers.
Results
Of 570 tissue specimens, 95 (16.7 percent) exhibited high-frequency microsatellite instability. Among 287 patients who did not receive adjuvant therapy, those with tumors displaying high-frequency microsatellite instability had a better five-year rate of overall survival than patients with tumors exhibiting microsatellite …
Total citations
Scholar articles
CM Ribic, DJ Sargent, MJ Moore, SN Thibodeau… - New England Journal of Medicine, 2003