Authors
Aileen M Davis, Brian O'Sullivan, Robert Turcotte, Robert Bell, Charles Catton, Pierre Chabot, Jay Wunder, Alex Hammond, Veronique Benk, Rita Kandel, Karen Goddard, Carolyn Freeman, Anna Sadura, Benny Zee, Andrew Day, Dongsheng Tu, Joseph Pater, A Canadian Sarcoma Group, NCI Canada Clinical Trials Group Randomized
Publication date
2005/4/1
Journal
Radiotherapy and oncology
Volume
75
Issue
1
Pages
48-53
Publisher
Elsevier
Description
BACKGROUND AND PURPOSE
This study compared late radiation morbidity in patients with extremity soft tissue sarcoma randomized to treatment by pre- (50Gy) or postoperative (66Gy) radiotherapy in combination with surgery. The morbidities evaluated included fibrosis, joint stiffness and edema at 2 years following treatment. The impact of morbidity on patient function as measured by the Musculoskeletal Tumor Rating Scale (MSTS) and the Toronto Extremity Salvage Score (TESS) was also evaluated.
PATIENTS AND METHODS
129 patients were evaluated. Toxicity rates were compared by treatment arm using the Fisher's exact test. Function scores by toxicity were analyzed using the Wilcoxon rank sum test. Multivariate logistic regression was used to evaluate the joint effect of treatment arm, field size, and dose on subcutaneous tissue fibrosis, joint stiffness and edema.
RESULTS
27 of 56 patients (48.2%) in …
Total citations
Scholar articles
AM Davis, B O'Sullivan, R Turcotte, R Bell, C Catton… - Radiotherapy and oncology, 2005