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This paper examines the broadening legacy of one of Wassily Leontief's major contributions — input-output (I-O) analysis. It identifies ways in which I-O continues to evolve and to serve as a vital tool of economic analysis. Moreover, many features of I-O, both conceptual and empirical, have been incorporated into computable general equilibrium (CGE) models. As noted, there are some important differences between the two approaches. However, I-O and CGE have much in common in terms of questions addressed, data requirements, range of applications, and future conceptual refinements.