Authors
Sirat Khan, Ross Davenport, Imran Raza, Simon Glasgow, Henry D De’Ath, Pär I Johansson, Nicola Curry, Simon Stanworth, Christine Gaarder, Karim Brohi
Publication date
2015/2
Journal
Intensive care medicine
Volume
41
Pages
239-247
Publisher
Springer Berlin Heidelberg
Description
Objective
To determine the effectiveness of blood component therapy in the correction of trauma-induced coagulopathy during hemorrhage.
Background
Severe hemorrhage remains a leading cause of mortality in trauma. Damage control resuscitation strategies target trauma-induced coagulopathy (TIC) with the early delivery of high-dose blood components such as fresh frozen plasma (FFP) and platelet transfusions. However, the ability of these products to correct TIC during hemorrhage and resuscitation is unknown.
Methods
This was an international prospective cohort study of bleeding trauma patients at three major trauma centers. A blood sample was drawn immediately on arrival and after 4, 8 and 12 packed red blood cell (PRBC) transfusions. FFP, platelet and cryoprecipitate use was recorded during these …
Scholar articles
S Khan, R Davenport, I Raza, S Glasgow, HD De'Ath… - Intensive care medicine, 2015