Authors
Vinod Kumar, Shih-Chin Cheng, Melissa D Johnson, Sanne P Smeekens, Agnieszka Wojtowicz, Evangelos Giamarellos-Bourboulis, Juha Karjalainen, Lude Franke, Sebo Withoff, Theo S Plantinga, Frank L Van De Veerdonk, Jos WM van Der Meer, Leo AB Joosten, Harry Sokol, Hermann Bauer, Bernhard G Herrmann, Pierre-Yves Bochud, Oscar Marchetti, John R Perfect, Ramnik J Xavier, Bart Jan Kullberg, Cisca Wijmenga, Mihai G Netea
Publication date
2014/9/8
Journal
Nature communications
Volume
5
Issue
1
Pages
4675
Publisher
Nature Publishing Group UK
Description
Candidaemia is the fourth most common cause of bloodstream infection, with a high mortality rate of up to 40%. Identification of host genetic factors that confer susceptibility to candidaemia may aid in designing adjunctive immunotherapeutic strategies. Here we hypothesize that variation in immune genes may predispose to candidaemia. We analyse 118,989 single-nucleotide polymorphisms (SNPs) across 186 loci known to be associated with immune-mediated diseases in the largest candidaemia cohort to date of 217 patients of European ancestry and a group of 11,920 controls. We validate the significant associations by comparison with a disease-matched control group. We observe significant association between candidaemia and SNPs in the CD58 (P=1.97 × 10−11; odds ratio (OR)=4.68), LCE4A-C1orf68 (P=1.98 × 10−10; OR=4.25) and TAGAP (P=1.84 × 10−8; OR=2.96) loci. Individuals carrying two or more …
Scholar articles
V Kumar, SC Cheng, MD Johnson, SP Smeekens… - Nature communications, 2014