Authors
Marisa K Joubert, Martha Hokom, Catherine Eakin, Lei Zhou, Meghana Deshpande, Matthew P Baker, Theresa J Goletz, Bruce A Kerwin, Naren Chirmule, Linda O Narhi, Vibha Jawa
Publication date
2012/7/20
Journal
Journal of Biological Chemistry
Volume
287
Issue
30
Pages
25266-25279
Publisher
Elsevier
Description
Background: Aggregated biotherapeutics have the potential to induce an immune response.
Results: Aggregates can enhance innate and adaptive immune responses of PBMC.
Conclusion: The response depends on aggregate type, immunogenicity of the monomer, donor immune status, and high particle numbers in the in vitro assay.
Significance: This is the first study showing the impact of aggregate characteristics on the potential immune response of PBMC.
Total citations
Scholar articles
MK Joubert, M Hokom, C Eakin, L Zhou, M Deshpande… - Journal of Biological Chemistry, 2012