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The goal of this article is to provide insight into how recent findings from affective science may be translated into the health arena. We first review definitional issues related to the key concepts of emotion and stress. We then review relevant research that informs our understanding of the affect–health relationship. Subsequently, we highlight findings that are the most informative and also ripe for translation into the domains of health and health-related behaviors. We identify several domains of affect-relevant processes (eg, emotion-regulation, stress response) that would benefit from increased elaboration. Three themes may guide how best to broaden our understanding across multiple domains: the need to use a differentiated emotion-based approach, the need to consider potential synergistic and oppositional effects of emotion that can occur in parallel, and the need to examine the impact …